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Xiao Yao Wan

Xiao Yao Wan (xiap yao san) is a famous formula used in Chinese herbal medicine. It was invented over a thousand years ago in China and is also known as Free and Easy Wanderer. It is called this as it allows the soul to better reside in the person's body.

It's principle actions are to:

  • Pacifies the Liver energy
  • Spreads Liver Qi
  • Strengthen Spleen function
  • Nourishe the Blood
  • Harmonise the Liver and Spleen

Benefits and uses

Xiao Yao Wan is used mainly in women to regulate their liver function. By regulating the liver, it helps to regulate a woman's menstrual cycle and fertility. It also reduces frustration and stress.

The liver is the most important organ in a woman. By improving a woman's liver, Xiao Yao Wan is greatly able to improve a woman's health.

As Xiao Yao Wan can regulate the menstrual cycle, it is commonly used to treat infertility or problems with the menstrual cycle such as pain, irregular menstrual cycle, dark blood and clots.

Xiao Yao Wan can also be used to treat emotional problems such as depression or anger.


Xiao Yao Wan contains the following natural herbs:

  • Chai Hu
  • Bai Shao
  • Dang Gui
  • Fu Ling
  • Bai Zhu
  • Sheng Jiang
  • Bo He
  • Zhi Gan Cao

Xiao yao wan can improve the effects of FSH drugs in women

Fifty-eight women with tubal infertility were randomized into two groups: 30 in an experimental group treated with Xiaoyao powder (Shugan) plus gonadotropin-releasing hormone analog (GnRHa)/follicle-stimulating hormone (FSH)/ human chorionic gonadotropin (hCG) and 28 in the control group who were treated with GnRHa/FSH/ hCG only.

The total gonadotropin (Gn) doses required, endometrial thickness, oocyte numbers, high quality embryo production rate and pregnancy rate of the two groups were compared.

The concentration of growth differentiation factor-9 (GDF-9) in follicular fluid was detected by western blotting and the expression of GDF-9 mRNA in granulosa cells was measured using reverse transcription-polymerase chain reaction amplification.

In the experimental group, the Gn dose was significantly lower than that in the control group; the endometrial thickness, high quality embryo production and pregnancy rates were significantly higher and the expression of GDF-9 mRNA was also significantly higher than in the control group (all P0.05).

Xiao Yao Wan can improve the pregnancy rate of women with tubal infertility; its mechanism is possibly related to the increased expression of GDF-9 in granulosa cells.


Gao, et al. (2013) Effect of soothing liver therapy on oocyte quality and growth differentiation factor-9 in patients undergoing in vitro fertilization and embryo transfer. J Tradit Chin Med; 33(5): 597-602.