Shan zhu yu improves sperm motility in men
An aqueous extract was prepared from the dried fruits of the herb and used in this study.
The crude extract at a final concentration of 0.5 microgram/micro liter in phosphate buffered saline (pH 7.4) increased sperm motility from 25.8 +/- 7.7% to 42.8 +/- 10.3% (i.e. 68% increase, n = 7), as determined by the computer-aided-sperm-analysis (CASA) method.
The crude extract was fractionated by high-performance liquid chromatography (HPLC) into four fractions: C1, C2, C3 and C4.
At a concentration of 5 ng/microliter, C4 increased the sperm motility from 15.7 +/- 3.8% to 34.5 +/- 6.4% (i.e. 120% increase, n = 6) by CASA and from 14.9 +/- 4.3 to 28.5 +/- 8.1 (i.e. 91% increase, n = 8) by transmembrane migration ratio (TMMR) method.
This result suggests that C4 is the active component in Cornus officinalis that enhances sperm motility.
Jeng et al. (1997) A substance isolated from Cornus officinalis enhances the motility of human sperm. Am J Chin Med; 25(3-4): 301-6 (ISSN: 0192-415X).